EMBRYO TRANSFER IN OOCYTE RECIPIENTS
Our practice is not differentiate recipients for ovarian function (acyclic or cyclic women). Its gives us the guarantee of good flexible schedule of treatment and in the most cases we use GnRH analog to get down regulation that gives us maximum of synchronization. But in some case when we sure that women have not ovarian activity we conduct hormone replacement therapy (HRT) protocols.
Thus women without active ovaries are started on HRT a few months prior to their planned treatment. Then we carefully assess of the endometrium to rule out patholo- gies such as endometrial polyps, inadequate endometrial thickness or hyperplastic endometrium.
The treatment is then synchronized with the donor's cycle.
Women with regular menstrual cycles vigorously undergo down- regulatin with a GnRH analog, and receive estradiol valerate (pills) or estradiol hemihydrate (transdermal form) in incremental doses to achieve endometrial growth.
Progesterone is added on the day after hCG administration for donors or at the donor's oocyte retrieval day.
Synchronization of donor and recipient cycles can be achieved in various ways but checking strong evidence of the temporal window of maximal endometrial receptivity.
Cryopreservation of the embryos and replacement at a later date may be need in some cases with problem of dys-synchrony of endometrium and embryos.